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Eloralintide (LY3841136): Selective Amylin Receptor Agonist — Research Overview

Eloralintide (LY3841136) is described in the literature as a selective, long-acting amylin receptor agonist peptide developed for once-weekly subcutaneous administration. Detailed primary sequence data were not confirmed in the sources reviewed here; this article does not assert

Identity and sequence

Eloralintide (LY3841136) is described as a selective, long-acting amylin receptor agonist peptide. A detailed primary amino-acid sequence was not confirmed in the sources used here, so no specific sequence is asserted.

Reported mechanism

The cited studies describe selective amylin-receptor pharmacology. This distinguishes the molecule from GLP-1 agonists and unimolecular incretin co-agonists; it does not imply that every amylin-family molecule or catalog formulation is interchangeable.

Primary literature

Bhattachar et al. (2026) report a phase 1 proof-of-concept study covering pharmacokinetics, tolerability and body-weight outcomes in human participants. Billings et al. (2025) report a 48-week randomized phase 2 study in participants with obesity. These are human clinical studies, not cell or rodent mechanistic experiments.

Limitations and prepared strengths

The 5 mg and 10 mg entries share molecule-family background. Clinical study materials and conditions do not establish the contents or outcomes of either prepared product. No sequence verification, human-use protocol or catalog efficacy claim follows from these references. This private article remains subject to review.

Related

References

  1. Bhattachar S et al. (2026). Eloralintide, a selective, long-acting amylin receptor agonist for treatment of obesity: Phase 1 proof of concept. [primary; human phase 1 proof-of-concept study]PMID: 41559929DOI: 10.1111/dom.70439
  2. Billings LK et al. (2025). Eloralintide, a selective amylin receptor agonist for the treatment of obesity: a 48-week phase 2, multicentre, double-blind, randomised, placebo-controlled trial. [primary; human phase 2 randomized trial]PMID: 41207310DOI: 10.1016/S0140-6736(25)02155-5

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