Identity and sequence
FOXO4-DRI is a D-retro-inverso synthetic peptide derived from a FOXO4 region involved in interaction with p53. It was designed to disrupt that protein interaction in senescent-cell research.
Originating model and mechanism
Baar et al. (2017) reported disruption of FOXO4–p53 interaction, p53 redistribution and apoptosis in the tested senescent-cell systems, with additional experiments in chemotoxicity and aging mouse models. Selectivity is an observation within those experiments, not a universal guarantee of sparing other cells.
Subsequent primary studies
Huang et al. (2021) investigated FOXO4-DRI in expanded human chondrocyte cultures. Kong et al. (2025) studied senescent keloid fibroblasts and p53-serine-15 phosphorylation/nuclear localization. Human-derived cells are not human clinical trials.
Tripathi et al. (2021) developed a distinct senolytic approach targeting the FOXO4–p53 complex. It supplies related mechanistic context and must not be presented as an experiment proving the exact FOXO4-DRI preparation’s activity.
Limitations and product evidence
These cell and rodent findings do not establish broad anti-aging effects or human treatment efficacy. The labeled 10 mg product requires independent identity and lot evidence. This article does not convert preclinical findings into a use or dosing recommendation.
Related
- foxo4 dri 10mgproduct
References
- Baar MP et al. (2017). Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. [primary; senescent-cell experiments and mouse models]PMID: 28340339DOI: 10.1016/j.cell.2017.02.031
- Huang Y et al. (2021). Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes. [primary; expanded human chondrocyte cultures]PMID: 33996787DOI: 10.3389/fbioe.2021.677576
- Tripathi U et al. (2021). Development of a novel senolytic by precise disruption of FOXO4-p53 complex. [primary; distinct FOXO4-p53 senolytic approach]PMID: 34768086DOI: 10.1016/j.ebiom.2021.103693
- Kong et al. (2025). FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation [primary; human keloid fibroblast experiments]DOI: 10.1038/s42003-025-07738-0
More questions?
Ask our Support Team — they can answer follow-up questions about this topic, COAs, storage, or anything else in the research library.
Tap the "Chat with us" tab on the right edge of any page.