Identity and sequence
MOTS-c is a 16-residue mitochondrial-derived peptide associated with the mitochondrial 12S rRNA gene region. Lee et al. (2015) described metabolic effects in experimental cell and mouse systems.
Primary metabolic and exercise research
The original Lee study linked MOTS-c to metabolic-homeostasis and AMPK-associated pathways in the systems tested. Reynolds et al. (2021) examined age-related physical performance in mice and also sampled endogenous MOTS-c responses around exercise in humans. Human sampling is not evidence that administering MOTS-c improved human performance.
Hyatt et al. (2022) investigated long-term physical activity and acute exercise responses in rodents. Those animal findings do not establish administered-MOTS-c effects in humans.
Review-level context
Yoon et al. (2022) review MOTS-c in exercise-related mitohormesis. A review’s broader mechanism synthesis must be distinguished from the individual primary experiments.
Limits for the SS-31 plus MOTS-c product
The label specifies SS-31 25 mg plus MOTS-c 25 mg. This article covers only MOTS-c component research. None of the cited primary studies evaluates that combined catalog preparation; no blend efficacy, human treatment effect or dosing recommendation is inferred.
Related
- ss 31 mots c 50mgproduct
References
- Lee C et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. [primary; cell and mouse metabolic experiments]PMID: 25738459DOI: 10.1016/j.cmet.2015.02.009
- Reynolds JC et al. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. [primary; mouse experiments plus human endogenous exercise sampling]PMID: 33473109DOI: 10.1038/s41467-020-20790-0
- Hyatt JK et al. (2022). MOTS-c increases in skeletal muscle following long-term physical activity and improves acute exercise performance after a single dose. [primary; rodent physical-activity and exercise experiments]PMID: 35808870DOI: 10.14814/phy2.15377
- Yoon TK et al. (2022). Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c). [review; exercise-related mitohormesis]PMID: 35656563DOI: 10.4093/dmj.2022.0092
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