Two distinct substance identities
Thymulin is a defined nine-residue peptide whose biological activity depends on zinc. Thymalin refers to a heterogeneous thymic polypeptide extract, not the same single peptide. Similar names do not establish chemical equivalence.
Primary thymulin evidence
Dardenne et al. (1985) used monoclonal antibodies, biological assays and immunofluorescence to examine a zinc-dependent epitope on thymulin. The work supports distinguishing zinc-coupled thymulin from zinc-deprived material; it does not identify a present catalog lot.
Thymalin literature is not thymulin evidence
the 2021 Thymalin review describes the extract and proposed biological mechanisms. Khavinson and Morozov (2003) report clinical observations involving thymalin and epithalamin. Those substances and study conditions do not establish thymulin identity or a product treatment claim.
Current product identity hold
This note is linked to the prepared thymulin-20mg record. The currently reviewed source accession 2607140482 has conflicting Thymalin/Thymulin naming. The product remains on identity hold; neither spelling is accepted as proof of the other identity. Resolving the exact current source, product, accession, lot and issuing-laboratory evidence is required before release. This is an identity note, not an efficacy endorsement.
Related
- thymulin 20mgproduct
References
- Dardenne M et al. (1985). A zinc-dependent epitope on the molecule of thymulin, a thymic hormone. [primary; antibody, biological and immunofluorescence assays]PMID: 2413455DOI: 10.1073/pnas.82.20.7035
- Khavinson VKh et al. (2003). Peptides of pineal gland and thymus prolong human life. [primary; clinical observations of thymalin and epithalamin, not thymulin]PMID: 14523363
- Khavinson et al. (2021). The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity [review; heterogeneous Thymalin extract]DOI: 10.1134/S2079086421040046
More questions?
Ask our Support Team — they can answer follow-up questions about this topic, COAs, storage, or anything else in the research library.
Tap the "Chat with us" tab on the right edge of any page.